INN monograph
Omeprazole/Domperidone
Proton Pump Inhibitor [EPC] · POM
Verified · Updated 01 Aug 2026 · Source: Local active-ingredient clinical extract; FDA drug label via OpenFDA/DailyMed; RxNorm (NLM RxNav); PubChem
Kenya market
Wholesale / list prices where loaded
Risk first
Contraindications
- [Omeprazole] [Omeprazole] Hypersensitivity to PPIs.
- Caution with rilpivirine and some antivirals (gastric pH). [bicarbonate] [From component Sodium bicarbonate] Hypertension
- convulsions
- metabolic and respiratory alkalosis
- hypocalcaemia in which alkalosis may produce tetany
- losing chloride by vomiting or by continous GI suction
- receiving diuretic that cause hypochloremic alkalosis. [Domperidone] [Domperidone] Hypersensitivity to PPIs.
- Caution with rilpivirine and some antivirals (gastric pH). [Esomeprazole] Hypersensitivity to PPIs.
- Caution with rilpivirine and some antivirals (gastric pH).
Precautions
- Warnings Allergy alert: do not use if you are allergic to omeprazole omeprazole may cause severe skin reactions.
- Symptoms may include: skin reddening blisters rash If an allergic reaction occurs, stop use and seek medical help right away.
- Do not use if you have: trouble or pain swallowing food, vomiting with blood, or bloody or black stools heartburn with lightheadedness, sweating or dizziness chest pain or shoulder pain with shortness of breath
- sweating
- pain spreading to arms, neck or shoulders
- or lightheadednes frequent chest pain These may be signs of a serious condition.
- See your doctor.
- Ask a doctor before use if you have : had heartburn over 3 months.
- This may be a sign of a more serious condition. frequent wheezing, particularly with heartburn unexplained weight loss nausea or vomiting stomach pain Ask a doctor or pharmacist before use if you are taking a prescription drug.
- Acid reducers may interact with certain prescription drugs.
- Stop use and ask doctor if: your heartburn continues or worsens you need to take this product for more than 14 days you need to take more than 1 course of treatment every 4 months you get diarrhea you develop a rash or joint pain If pregnant or breast-feeding, ask a health professional before use.
- Keep out of reach of children.
Point of care
Dosing
Adult
Directions for adults 18 years of age and older this product is to be used once a day (every 24 hours), every day for 14 days it may take 1 to 4 days for full effect; some people get complete relief of symptoms within 24 hours 14-Day Course of Treatment swallow 1 tablet with a glass of water before eating in the morning take every day for 14 days do not take more than 1 tablet a day do not use for more than 14 days unless directed by your doctor swallow whole. Do not chew or crush tablets Repeated 14-Day Courses (if needed) you may repeat a 14-day course every 4 months do not take for more than 14 days or more often than every 4 months unless directed by a doctor children under 18 years of age: ask a doctor. Heartburn in children may sometimes be caused by a serious condition.
Paediatric
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Renal
Rare AIN; otherwise minimal renal dosing issues.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Hepatic
Severe hepatic impairment: dose reduction for some agents.
Safety
Drug interactions
- Fixed-dose/multi-ingredient product.
- Clinical details partially inherited from component monographs: Omeprazole, Domperidone.
- Confirm combination SmPC for exact dosing.
Safety
Adverse effects
- [From component Omeprazole] Candidiasis, GI disturbances, skin rashes, photosensitivity, stomatitis blood dyscrasia, hypersensitivity, CNS effects, paraesthesia, malaise, alopecia, muscle weakness, myalgia, peripheral oedema, gynaecomatia, hepatitis.
Use
Indications
- Use(s) treats frequent heartburn (occurs 2 or more days a week) not intended for immediate relief of heartburn
- this drug may take 1 to 4 days for full effect Clinical selection for Omeprazole/Domperidone should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC.
- Class context: Proton Pump Inhibitor [EPC].
- Confirm site-specific dose, duration and monitoring before prescribing.
Pharmacology
Mode of action
Combination product.
Full mechanism text
Combination product. Component mechanism (Omeprazole): Inhibits H+/K+-ATPase in parietal cells, blocking final step of acid production. PPIs irreversibly inhibit the gastric H+/K+-ATPase (proton pump) in parietal cells, suppressing basal and stimulated acid secretion — the most potent pharmacological acid suppression.
ADME
Pharmacokinetics & PD
| Onset | 1–2 hours; full acid suppression days |
|---|---|
| Duration | 24 hours+ (irreversible pump inhibition) |
| Route | ORAL / IV |
| Metabolism | (polymorphisms affect levels). Short plasma |
| Half-life | but prolonged pharmacodynamic effect. |
Kenya
Brands & prices
| Brand | Company | Pack | KES |
|---|---|---|---|
| Limzer | Mega Lifesciences | Standard Commercial Pack | — |
| LIMZER 3*10 | DAIMA BIASHARA / Wholesale Import | TABS | 849.60 |
Special populations
Pregnancy & lactation
Pregnancy
[Omeprazole] [Omeprazole] Often used when indicated; omeprazole has substantial human data — still risk–benefit. [bicarbonate] Usage in Pregnancy All components of Elliotts B Solution are normal body constituents. Animal reproduction studies have not been conducted with Elliotts B Solution. [Domperidone] [Domperidone] Often used when indicated; omeprazole has substantial human data — still risk–benefit. [Esomeprazole] Often used when indicated; omeprazole has substantial human data — still risk–benefit.
Lactation
Generally considered acceptable; infant exposure low.
Diet
Food & alcohol
- Food
- Food
Trust
Sources & disclaimer
Source: Local active-ingredient clinical extract; FDA drug label via OpenFDA/DailyMed; RxNorm (NLM RxNav); PubChem
Last reviewed: 01 Aug 2026
Decision support only — not a substitute for clinical judgment, product SmPC, or Kenya STG/EML.