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← Results for “Paracetamol” | Serratiopeptidase /Diclofenac/ Paracetamol

INN monograph

Serratiopeptidase /Diclofenac/ Paracetamol

Non-opioid analgesic / antipyretic · POM

POM

Verified · Updated 01 Aug 2026 · Source: Local active-ingredient clinical extract; PubChem; Component monographs (multi-source pipeline); Professional class pharmacology (Non-opioid analgesic / antipyretic)

Class
Non-opioid analgesic / antipyretic
Schedule
POM
Route
ORAL / RECTAL / IV
Onset
30–60 minutes oral
Duration
4–6 hours
Pregnancy
[Serratiopeptidase] Anal...
Renal
Generally safe; prolonge...
High-alert
No

Kenya market

Wholesale / list prices where loaded

From
Median
Brands
1

Risk first

Contraindications

  • [Serratiopeptidase] Severe active hepatic disease / acute liver failure.
  • Hypersensitivity.
  • Chronic heavy alcohol use — use reduced maximum daily dose or avoid. [Diclofenac] Active peptic ulcer / GI bleeding.
  • Severe heart failure.
  • NSAID-exacerbated respiratory disease (aspirin-sensitive asthma) for non-selective agents.
  • Third trimester pregnancy (ductus arteriosus, oligohydramnios — class warning).
  • Severe renal impairment for many agents.
  • Hypersensitivity to NSAIDs. [Paracetamol] Severe active hepatic disease / acute liver failure.
  • Hypersensitivity.
  • Chronic heavy alcohol use — use reduced maximum daily dose or avoid.

Precautions

  • [From component Diclofenac] Warnings For external use only Allergy alert: Diclofenac may cause a severe allergic reaction, especially in people allergic to aspirin.
  • Symptoms may include: hives asthma (wheezing) skin reddening blisters facial swelling shock rash If an allergic reaction occurs, stop use and seek medical help right away.
  • Liver warning: This product contains diclofenac.
  • Liver damage may occur if you apply more or for a longer time than directed when using other drugs containing diclofenac Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.
  • The chance is small but higher if you are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product apply more or for longer than directed Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke.
  • These can be fatal.
  • The risk is higher if you use more than directed or for longer than directed.
  • Do not use if you have ever had an allergic reaction to any other pain reliever or to a fever reducer for strains, sprains, bruises or sports injuries.
  • This product has not been shown to work for these types of injuries. right before or after heart surgery on more than 2 body areas at the same time in the eyes, nose or mouth Ask a doctor before us if you have problems or serious side effects from taking pain relievers or fever reducers stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke you are taking a diuretic you are under age 18 years.
  • It is not known if this drug works or is safe in children under age 18 years.
  • Ask a doctor or pharmacist before use if you are under a doctor’s care for any serious condition taking any other drug When using this product avoid contact with eyes, nose, or mouth if eye contact occurs, rinse thoroughly with water Stop use and ask a doctor if pain gets worse or lasts more than 21 days redness or swelling is present in the painful area fever occurs skin irritation occurs any new symptoms appear.
  • These could be signs of a serious condition. you experience any of the following signs of stomach bleeding: feel faint have bloody or black stools vomit blood have stomach pain that does not get better you have symptoms of heart problems or stroke: chest pain trouble breathing leg swelling weakness in one part or side of body slurred speech If pregnant or breast-feeding, ask a health professional before use.

Point of care

Dosing

Adult

Dosing is indication-, age-, weight- and organ-function-specific for this INN. Do not use class averages for high-risk patients. Confirm the exact regimen in the current SmPC and Kenya Standard Treatment Guidelines. Typical professional workflow: (1) confirm indication, (2) check renal/hepatic function, (3) screen interactions/allergies, (4) select dose/route/duration, (5) define monitoring.

Paediatric

Paediatric dosing is weight- and age-based; use a paediatric formulary / SmPC. Do not extrapolate adult tablets without calculation.

Renal

Generally safe; prolonged high dose rare associations — prefer careful use in advanced CKD.

  • CrCl 0–120: Confirm renal dosing in product SmPC / primary label.

Hepatic

PRIMARY toxicity organ in overdose; therapeutic doses usually safe if daily limits respected.

Safety

Drug interactions

Open checker →
  • Fixed-dose/multi-ingredient product.
  • Clinical details partially inherited from component monographs: Diclofenac, Paracetamol.
  • Confirm combination SmPC for exact dosing.

Safety

Adverse effects

  • [From component Diclofenac] GIT disturbances, GIT ulceration, headache, dizziness, vertigo, tinnitus, taste alteration, blood dyscrasia, renal, hepatic disorders.

Use

Indications

  • Therapeutic use is agent- and indication-specific within the class (Non-opioid analgesic / antipyretic).
  • Use according to culture results, national guidelines (Kenya STG/EML where applicable) and the current product SmPC.
  • Pain and inflammation

Pharmacology

Mode of action

Combination product.

Inhibit COX ↓ Prostaglandins Analgesia / anti-inflammatory
Full mechanism text

Combination product. Component mechanism (Diclofenac): It acetylates prostaglandin endoperoxide synthase and irreversibly inhibits its cyclo-oxygenase [COX] activity. This enzyme catalyzes the conversion of arachidonic acid to PGH2.It has two isoforms: COX-1 and COX-2. Acetylation of platelet cyclo-oxygenase prevents synthesis of thromboxane A2 [a potent vasoconstrictor and inducer of platelet aggregation].

ADME

Pharmacokinetics & PD

Onset 30–60 minutes oral
Duration 4–6 hours
Route ORAL / RECTAL / IV
Metabolism (glucuronidation/sulfation); toxic NAPQI pathway via CYP2E1 when pathways saturated or glutathione depleted.
Half-life ~2–3 h; prolonged in liver disease/overdose.
Full PK/PD text

Rapid oral absorption. Hepatic metabolism (glucuronidation/sulfation); toxic NAPQI pathway via CYP2E1 when pathways saturated or glutathione depleted. Half-life ~2–3 h; prolonged in liver disease/overdose.

Kenya

Brands & prices

1 listed
Brand Company Pack KES
Enzoflam Alkem Laboratories Ltd. Standard Commercial Pack

Special populations

Pregnancy & lactation

Pregnancy

[Serratiopeptidase] Analgesic/antipyretic of choice in pregnancy when needed; use lowest effective dose/shortest duration. [Diclofenac] [Diclofenac] Avoid in third trimester. Earlier pregnancy: use only if needed; prefer paracetamol first-line. [Methyl Salicylate] Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist. [Linseed Oil] Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist. [Paracetamol] Analgesic/antipyretic of choice in pregnancy when needed; use lowest effective dose/shortest duration.

Lactation

[Diclofenac] [Diclofenac] Short-course ibuprofen generally acceptable; avoid chronic high-dose/long half-life agents when possible. [Methyl Salicylate] Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data. [Linseed Oil] Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data.

Diet

Food & alcohol

  • Food
  • Food

Trust

Sources & disclaimer

Source: Local active-ingredient clinical extract; PubChem; Component monographs (multi-source pipeline); Professional class pharmacology (Non-opioid analgesic / antipyretic)

Open source link

Last reviewed: 01 Aug 2026

Decision support only — not a substitute for clinical judgment, product SmPC, or Kenya STG/EML.

Kenya Verified Health Registry