INN monograph
Ciprofloxacin Hydrochloride
Fluoroquinolones · POM
Verified · Updated 23 Jul 2026
Kenya market
Wholesale / list prices where loaded
Risk first
Contraindications
No structured CI text — verify product SmPC.
Point of care
Dosing
Adult
See SmPC / STG for indication-specific dose.
Paediatric
Weight-based — use paediatric formulary / SmPC.
Renal
Check SmPC; many renally cleared drugs need CrCl adjustment.
Hepatic
Check SmPC in significant liver disease.
Safety
Drug interactions
No structured interaction monograph text. Use the multi-drug checker and SmPC.
Safety
Adverse effects
ADR text pending — consult SmPC.
Use
Indications
PPB Registered Human Medicine.
Pharmacology
Mode of action
Fluoroquinolone: inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, blocking DNA replication and producing concentration-dependent bactericidal activity.
Full mechanism text
Fluoroquinolone: inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, blocking DNA replication and producing concentration-dependent bactericidal activity.
ADME
Pharmacokinetics & PD
| Route | ORAL |
|---|
Kenya
Brands & prices
| Brand | Company | Pack | KES |
|---|---|---|---|
| Cifin | Cosmos Limited | Film-Coated Tablet (36 months) | 409.00 |
| Cifin 500mg | Elys Chemical Industries Ltd | Film-Coated Tablet (36 months) | 1,394.00 |
| Ciflo | PFIZER LABORATORIES LTD | Film-Coated Tablet (36 months) | 1,262.00 |
| Ciflo 500mg | RADIANCE PHARMACEUTICALS LTD | Film-Coated Tablet (36 months) | 1,500.00 |
| Cipro-Denk | Medivet Products Ltd | Film-Coated Tablet (36 months) | 701.00 |
| Cipro-Denk 500mg | RADIANCE PHARMACEUTICALS LTD | Film-Coated Tablet (36 months) | 178.00 |
| Ciprobay | Regal Pharmaceuticals Ltd | Film-Coated Tablet (36 months) | 1,053.00 |
| Ciprobay 500mg | Medivet Products Ltd | Film-Coated Tablet (36 months) | 1,334.00 |
| Ciprocos | Regal Pharmaceuticals Ltd | Film-Coated Tablet (36 months) | 1,129.00 |
| Ciprocos 500mg | Surgipharm Ltd | Film-Coated Tablet (36 months) | 254.00 |
Special populations
Pregnancy & lactation
Pregnancy
See SmPC / obstetric guidance.
Lactation
See SmPC / lactation reference.
Diet
Food & alcohol
- Milk & Calcium-Rich Foods (Dairy, Yogurt, Cheese, Calcium Antacids) Polyvalent calcium cations chelate with fluoroquinolone molecules in the gut, reducing oral drug absorption by 50% to 70%. Administer at least 2 hours before or 6 hours after dairy or calcium-fortified products.
- Caffeine (Coffee, Tea, Energy Drinks) Inhibits hepatic CYP1A2 metabolism of caffeine, leading to elevated caffeine levels, cardiac palpitations, nervousness, tremors, and insomnia.
Trust
Sources & disclaimer
Source: MyDrugIndex clinical corpus
Decision support only — not a substitute for clinical judgment, product SmPC, or Kenya STG/EML.