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Classes Check interactions

INN monograph

Levofloxacin hemihydrate USP

J01MA12 · POM

PPB Registered POM

Verified · Updated 23 Jul 2026

Patient advice Interactions

Class

J01MA12

Schedule

POM

Route

Solution For Infusion

Onset

—

Duration

—

Pregnancy

See notes

Renal

Check SmPC

High-alert

Kenya market

Wholesale / list prices where loaded

From

KES 535

Median

KES 535

Brands

Risk first

Contraindications

No structured CI text — verify product SmPC.

Point of care

Dosing

Adult

See SmPC / STG for indication-specific dose.

Paediatric

Weight-based — use paediatric formulary / SmPC.

Renal

Check SmPC; many renally cleared drugs need CrCl adjustment.

Hepatic

Check SmPC in significant liver disease.

Safety

Drug interactions

Open checker →

No structured interaction monograph text. Use the multi-drug checker and SmPC.

Safety

Adverse effects

ADR text pending — consult SmPC.

Use

Indications

PPB Registered Human Medicine.

Pharmacology

Mode of action

Fluoroquinolone: inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, blocking DNA replication and producing concentration-dependent bactericidal activity.

Inhibit DNA gyrase / topo IV → Block replication → Bactericidal

Full mechanism text

Fluoroquinolone: inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, blocking DNA replication and producing concentration-dependent bactericidal activity.

ADME

Pharmacokinetics & PD

Route	Solution For Infusion

Kenya

Brands & prices

1 listed

Brand	Company	Pack	KES
LOXAMOX Solution for Infusion (500mg/100ml)	dina.abukhalaf@mspharma.com	H2020/CTD6906/13397 (36 months)	535.00

Special populations

Pregnancy & lactation

Pregnancy

See SmPC / obstetric guidance.

Lactation

See SmPC / lactation reference.

Diet

Food & alcohol

Milk & Calcium-Rich Foods (Dairy, Yogurt, Cheese, Calcium Antacids) Polyvalent calcium cations chelate with fluoroquinolone molecules in the gut, reducing oral drug absorption by 50% to 70%. Administer at least 2 hours before or 6 hours after dairy or calcium-fortified products.
Caffeine (Coffee, Tea, Energy Drinks) Inhibits hepatic CYP1A2 metabolism of caffeine, leading to elevated caffeine levels, cardiac palpitations, nervousness, tremors, and insomnia.

Trust

Sources & disclaimer

Source: MyDrugIndex clinical corpus

Decision support only — not a substitute for clinical judgment, product SmPC, or Kenya STG/EML.