INN monograph
Ext. of valerian 200 mg, Ext. of golden root, Ext. of hawthorn 56 mg, Ext. of passion flower 30 mg, Magnesium citrate 200 mg
Vitamin / mineral / nutritional supplement · POM
Verified · Updated 01 Aug 2026 · Source: Local active-ingredient clinical extract; Professional class pharmacology (Vitamin / mineral / nutritional supplement)
Kenya market
Wholesale / list prices where loaded
Risk first
Contraindications
- Hypervitaminosis risk states (hypercalcaemia for vitamin D/A).
- Iron: avoid in iron overload.
- Potassium: severe hyperkalaemia / untreated Addison's.
Precautions
- Treat confirmed deficiency with monitored repletion.
- Avoid megadoses without indication.
- Iron: keep away from children (overdose lethal).
Point of care
Dosing
Adult
Dosing is indication-, age-, weight- and organ-function-specific for this INN. Do not use class averages for high-risk patients. Confirm the exact regimen in the current SmPC and Kenya Standard Treatment Guidelines. Typical professional workflow: (1) confirm indication, (2) check renal/hepatic function, (3) screen interactions/allergies, (4) select dose/route/duration, (5) define monitoring.
Paediatric
Paediatric dosing is weight- and age-based; use a paediatric formulary / SmPC. Do not extrapolate adult tablets without calculation.
Renal
Fat-soluble vitamins and potassium need care in advanced CKD.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Hepatic
Vitamin A toxicity hepatic; niacin hepatotoxicity at high dose.
Safety
Drug interactions
- Extract of valerian (Valeriana officinalis L.) 200 mg standardised to 0.25 % valerenic acid.
- Extract of golden root (Rhodiola rosea) 150 mg standardised to 3 % rosavin and 1 % salidroside.
- Extract of hawthorn (Crataegus monogyna Jacq.) 56 mg standardised to 15 % procyanidins and 2.3 % flavonoids.
- Extract of passion flower (Passiflora incarnata) 30 mg standardized to 3.5 % flavonoids.
- Magnesium citrate 200 mg.
Safety
Adverse effects
- GI upset (iron, high-dose vitamin C).
- Hypercalcaemia (vitamin D excess).
- Neuropathy with B6 megadoses.
- Flushing (niacin).
Use
Indications
- Product Label Claim: short-term stress, anxiety or tension.
- It is suitable for adults and for children over 12 years old.
- Clinical selection for Ext. of valerian 200 mg, Ext. of golden root, Ext. of hawthorn 56 mg, Ext. of passion flower 30 mg, Magnesium citrate 200 mg should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC.
- Class context: Vitamin / mineral / nutritional supplement.
- Confirm site-specific dose, duration and monitoring before prescribing.
Pharmacology
Mode of action
Vitamins and minerals act as cofactors, antioxidants, structural elements or hormone precursors (e.
Full mechanism text
Vitamins and minerals act as cofactors, antioxidants, structural elements or hormone precursors (e.g. vitamin D endocrine axis). Pharmacological high-dose effects differ from nutritional repletion.
ADME
Pharmacokinetics & PD
| Onset | Days–weeks for repletion |
|---|---|
| Duration | Depends on stores and ongoing intake |
| Route | ORAL / IM / IV (selected) |
| Absorption | depends on GI integrity, food matrix and binders (e.g. calcium/iron interactions). Fat-soluble vitamins (A,D,E,K) accumulate; water-soluble generally renally cleared. |
Kenya
Brands & prices
| Brand | Company | Pack | KES |
|---|---|---|---|
| CalmiRelax | Pharma Bavaria | Standard Commercial Pack | — |
Special populations
Pregnancy & lactation
Pregnancy
Folic acid preconception/first trimester critical. Iron/folate common in ANC. Avoid excess vitamin A.
Lactation
Maternal repletion often appropriate; avoid megadoses.
Diet
Food & alcohol
- Food
- Food
Trust
Sources & disclaimer
Source: Local active-ingredient clinical extract; Professional class pharmacology (Vitamin / mineral / nutritional supplement)
Last reviewed: 01 Aug 2026
Decision support only — not a substitute for clinical judgment, product SmPC, or Kenya STG/EML.