INN monograph
Adsorbed Tetanus Vaccine, Serum
Vaccine / immunological product · POM
Verified · Updated 01 Aug 2026 · Source: Local active-ingredient clinical extract; Professional class pharmacology (Vaccine / immunological product)
Kenya market
Wholesale / list prices where loaded
Risk first
Contraindications
- Anaphylaxis to prior dose or component.
- Live vaccines contraindicated in significant immunosuppression and usually pregnancy.
- Defer for moderate–severe acute illness.
Precautions
- Observe 15 minutes post-dose if high anaphylaxis concern.
- Correct injection technique and site.
- Report AEFI via national systems.
Point of care
Dosing
Adult
Dosing is indication-, age-, weight- and organ-function-specific for this INN. Do not use class averages for high-risk patients. Confirm the exact regimen in the current SmPC and Kenya Standard Treatment Guidelines. Typical professional workflow: (1) confirm indication, (2) check renal/hepatic function, (3) screen interactions/allergies, (4) select dose/route/duration, (5) define monitoring.
Paediatric
Paediatric dosing is weight- and age-based; use a paediatric formulary / SmPC. Do not extrapolate adult tablets without calculation.
Renal
N/A generally.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Hepatic
N/A generally.
Safety
Drug interactions
- Follow Kenya KEPI / MoH schedules.
- Never freeze freeze-sensitive vaccines incorrectly.
- Document batch and site.
- Separate true contraindications from precautions.
Safety
Adverse effects
- Local pain, low-grade fever, myalgia.
- Serious: anaphylaxis, vaccine-specific rare events (e.g. intussusception historically with some rotavirus products).
Use
Indications
- Therapeutic use is agent- and indication-specific within the class (Vaccine / immunological product).
- Use according to culture results, national guidelines (Kenya STG/EML where applicable) and the current product SmPC.
- Passive immunisation gainst tetanus
Pharmacology
Mode of action
Vaccines present antigen to the adaptive immune system to generate protective antibodies and memory cells without causing full disease (or using attenuated/inactivated/subunit/mRNA platforms).
Full mechanism text
Vaccines present antigen to the adaptive immune system to generate protective antibodies and memory cells without causing full disease (or using attenuated/inactivated/subunit/mRNA platforms). Immunoglobulins provide passive temporary immunity.
ADME
Pharmacokinetics & PD
| Onset | Immune response days–weeks |
|---|---|
| Duration | Months–lifelong (schedule-dependent) |
| Route | IM / SC / ORAL / ID |
Kenya
Brands & prices
| Brand | Company | Pack | KES |
|---|---|---|---|
| No brands linked yet. | |||
Special populations
Pregnancy & lactation
Pregnancy
Inactivated vaccines (e.g. influenza, Tdap) often recommended; live vaccines generally avoided.
Lactation
Most vaccines compatible; live vaccines usually fine for breastfeeding mother.
Diet
Food & alcohol
- Food
Trust
Sources & disclaimer
Source: Local active-ingredient clinical extract; Professional class pharmacology (Vaccine / immunological product)
Last reviewed: 01 Aug 2026
Decision support only — not a substitute for clinical judgment, product SmPC, or Kenya STG/EML.